The Partners Human Research Committee (PHRC) is the IRB of Mass General Brigham. The PHRC must approve all human-subject research conducted by a Mass General Brigham-affiliated investigator.
Under FDA regulations, an IRB is an appropriately constituted group that has been formally designated to review and monitor biomedical research involving human subjects. In accordance with FDA regulations, an IRB has the authority to approve, require modifications to secure approval, or disapprove research. Source: FDA.gov.